P.002 Increased epileptiform activity during N2 and slow wave sleep in Alzheimer’s Disease

Background: Recent evidence shows that epileptiform activity (EA) in sleep can present early Alzheimer’s Disease (AD) with faster cognitive decline. Existing literature examining sleep, AD and seizures is mostly qualitative. We conducted a systematic review to quantify the stage most associated EA amnestic mild impairment (aMCI)Methods: searched MEDLINE Embase using MeSH terms: “Alzheimer’s Disease” AND “Epilepsy” OR “Seizures’’ “Sleep” “REM” (rapid eye movement sleep). extracted data determine distribution across stages. averaged percentages studies. If study had aMCI subgroups, we represent study. Results: 4/14 articles quantitative from total of 111 or patients. Most occurred non-REM (N2; 36.1±17.8%). next frequently slow-wave (SWS; 34.1±9.9%), N1 (15.5±6.7%), REM (14.4±11.6%). Conclusions: N2 were aMCI. This suggests importance therapeutic interventions may decrease increase REM. Future studies could explore whether it quantity quality EA.